CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
The lectin-like domain of thrombomodulin interferes with complement activation and protects against diabetic nephropathy
DOI 10.1055/s-0030-1254018
Bibliografische Angaben
Nachweis in CareLit
Autor:innenH Wang, V Ilya, Q Zhou, T He, M Thati, K Shahzad, M Kashif, J Wolter, A Bierhaus, P Nawroth, B Isermann
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe04/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Thrombomodulin (TM) is predominantly a vascular endothelial cell plasma membrane glycoprotein that, via distinct structural domains, interacts with multiple ligands, thereby modulating coagulation, fibrinolysis, complement activation, inflammation and cell proliferation. We have previously shown that TM protects against diabetic nephropathy (DN) through activation of protein C(PC), which inhibits glome…
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Zitierempfehlung
H Wang, V Ilya, Q Zhou, T He, M Thati, K Shahzad, M Kashif, J Wolter, A Bierhaus, P Nawroth, B Isermann (2010) The lectin-like domain of thrombomodulin interferes with complement activation and protects against diabetic nephropathy. Diabetologie und Stoffwechsel (04). https://doi.org/10.1055/s-0030-1254018
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