CareLit · DOI-Nachweis · Klinische Pädiatrie
Prevalence and prognostic significance of chromosome 21 amplifications in children with relapsed acute lymphoblastic leukemia: the ALL-REZ BFM study group
DOI 10.1055/s-0030-1254455
Bibliografische Angaben
Nachweis in CareLit
Autor:innenS Krentz, J Hof, E Klopocki, G Körner, F Troitier, C Steinhoff, K Seeger, S Mundlos, C Hagemeier, A von Stackelberg, G Henze, C Eckert, R Kirschner-Schwabe
ZeitschriftKlinische Pädiatrie
Ausgabe05/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Survival after relapse of childhood ALL is currently predicted from clinical factors; however, the underlying molecular determinants are poorly understood. To identify chromosomal alterations associated with prognosis, we screened 223 patients with first relapse of B-cell precursor ALL by multiplex ligation-dependent probe amplification (MLPA). Gains of chromosome 21 (chr21) were the most frequent alterations (41%)…
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Zitierempfehlung
S Krentz, J Hof, E Klopocki, G Körner, F Troitier, C Steinhoff, K Seeger, S Mundlos, C Hagemeier, A von Stackelberg, G Henze, C Eckert, R Kirschner-Schwabe (2010) Prevalence and prognostic significance of chromosome 21 amplifications in children with relapsed acute lymphoblastic leukemia: the ALL-REZ BFM study group. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0030-1254455
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