CareLit · DOI-Nachweis · Klinische Pädiatrie
Intact apoptosis signaling in pediatric ALL is associated with patient outcome, low expression of anti-apoptotic molecules and long NOD/SCID engraftment
DOI 10.1055/s-0030-1254461
Bibliografische Angaben
Nachweis in CareLit
Autor:innenF Seyfried, M Queudeville, SM Eckhoff, KM Debatin, LH Meyer
ZeitschriftKlinische Pädiatrie
Ausgabe05/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
We recently reported the importance of intact apoptosis signaling for treatment response in pediatric ALL and AML analyzing two key apoptogenic events, cytochrome c release and caspase-3 activation. In a NOD/SCID/huALL xenograft model we found that rapid in vivo leukemia growth (Time to leukemia (TTL) short) in mice determines poor patient outcome. In this study we investigated apoptosis signaling and expression of…
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Zitierempfehlung
F Seyfried, M Queudeville, SM Eckhoff, KM Debatin, LH Meyer (2010) Intact apoptosis signaling in pediatric ALL is associated with patient outcome, low expression of anti-apoptotic molecules and long NOD/SCID engraftment. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0030-1254461
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