CareLit · DOI-Nachweis · Klinische Pädiatrie
Positive evidence for a role of the PML pathway in leukemogenesis of acute promyelocytic leukemia
DOI 10.1055/s-0030-1254462
Bibliografische Angaben
Nachweis in CareLit
Autor:innenT Sternsdorf, C Ocampo-Bayuga, A Haschke, K Dierk, S Prall, M Horstmann, RM Evans
ZeitschriftKlinische Pädiatrie
Ausgabe05/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Acute Promyelocytic Leukemia is characterized by the production of oncogenic Retinoic acid receptor alpha (RARα) fusion proteins. The most frequently observed fusion protein is PML-RAR (PR). All fusion partners of RARα contribute an oligomerization motif. Previously, we have shown that replacement of PML with an unrelated oligomerization domain renders RARα oncogenic, albeit also reduces its potency. Here we have, c…
Zitieren
Zitierempfehlung
T Sternsdorf, C Ocampo-Bayuga, A Haschke, K Dierk, S Prall, M Horstmann, RM Evans (2010) Positive evidence for a role of the PML pathway in leukemogenesis of acute promyelocytic leukemia. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0030-1254462
Mit CareLit weiterarbeiten