CareLit · DOI-Nachweis · Klinische Pädiatrie
The DNA-binding protein YB-1 is a direct MYCN target and influences repair and resistance in neuroblastoma cell lines
DOI 10.1055/s-0030-1254471
Bibliografische Angaben
Nachweis in CareLit
Autor:innenS Degen, S Kuhfittig-Kulle, JH Schulte, F Westermann, A Schramm, A Eggert, K Astrahantseff
ZeitschriftKlinische Pädiatrie
Ausgabe05/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
YB-1 regulates both gene transcription and translation, and increased YB-1 expression and nuclear localization has been associated with aggressive cancer phenotypes. We examined YB-1 expression, assessed the effect of YB-1 knockdown on cell viability and repair capacity and transcriptional control via MYCN in neuroblastoma (NB) cell models. YB-1 was expressed in NB cell lines, and expression was elevated in a cispla…
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Zitierempfehlung
S Degen, S Kuhfittig-Kulle, JH Schulte, F Westermann, A Schramm, A Eggert, K Astrahantseff (2010) The DNA-binding protein YB-1 is a direct MYCN target and influences repair and resistance in neuroblastoma cell lines. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0030-1254471
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