CareLit · DOI-Nachweis · Klinische Pädiatrie
Finding the key of antifolate virtue – investigation of effects on the epigenetic level
DOI 10.1055/s-0030-1254486
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Nachweis in CareLit
Autor:innenA Groenhagen, J Muehlisch, A Niemann, R Singh, JK Sandhu, J Boos, M Fruehwald, G Hempel
ZeitschriftKlinische Pädiatrie
Ausgabe05/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Due to their mode of action antifolates may lead to instability of DNA molecules as well as demethylation of cytosine residues, what could subsequently result in activation of epigenetically silenced genes. Therefore, we investigated the epigenetic effects of the two classical antifolates methotrexate (MTX) and pemetrexed (PMX) in cell lines. Methods: We performed cytotoxicity assays to determine optim…
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Zitierempfehlung
A Groenhagen, J Muehlisch, A Niemann, R Singh, JK Sandhu, J Boos, M Fruehwald, G Hempel (2010) Finding the key of antifolate virtue – investigation of effects on the epigenetic level. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0030-1254486
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