CareLit · DOI-Nachweis · Klinische Pädiatrie
Evaluation of p53 function in ETV6/RUNX1 positive leukemia
DOI 10.1055/s-0030-1254488
Bibliografische Angaben
Nachweis in CareLit
Autor:innenU Kaindl, G Fuka, G Krapf, M Kauer, R Panzer-Gruemayer
ZeitschriftKlinische Pädiatrie
Ausgabe05/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
ETV6/RUNX1 (ER) initiates leukemia development but is insufficient to generate overt leukemia by itself. The high number of secondary alterations in these leukemias suggests that DNA damage response is attenuated by the fusion gene, an assumption that is supported by microarray data from primary ALL. Based on its central role as guardian of genomic integrity, we focused on p53 and its regulation by ER. While transie…
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Zitierempfehlung
U Kaindl, G Fuka, G Krapf, M Kauer, R Panzer-Gruemayer (2010) Evaluation of p53 function in ETV6/RUNX1 positive leukemia. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0030-1254488
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