CareLit · DOI-Nachweis · Klinische Pädiatrie
The dimerization domains of MLL are potential therapeutic targets in t(4;11)-leukemias
DOI 10.1055/s-0030-1254491
Bibliografische Angaben
Nachweis in CareLit
Autor:innenB Pless, C Oehm, T Dingermann, R Marschalek
ZeitschriftKlinische Pädiatrie
Ausgabe05/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The human MLL protein – as well as the leukemogenic AF4-MLL fusion protein are specifically hydrolyzed by the endopeptidase Taspase1. The resulting protein fragments are able to form an intramolcular dimer which is necessary for complex formation and stability of both proteins. We have dissected the two dimerization domains, named FYRN and FYRC, by B-2-H experiments, pull-down experiments using recombinant proteins…
Zitieren
Zitierempfehlung
B Pless, C Oehm, T Dingermann, R Marschalek (2010) The dimerization domains of MLL are potential therapeutic targets in t(4;11)-leukemias. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0030-1254491
Mit CareLit weiterarbeiten