CareLit · DOI-Nachweis · Klinische Pädiatrie
Taspase1: unraveling its control mechanisms
DOI 10.1055/s-0030-1254492
Bibliografische Angaben
Nachweis in CareLit
Autor:innenS Sabiani, T Geppert, G Schneider, T Dingermann, R Marschalek
ZeitschriftKlinische Pädiatrie
Ausgabe05/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Taspase1 is a highly specific endoprotease that hydrolyzes the MLL protein at the two 7mer cleavage sites, CS1 and CS2, respectively. The proteolytic cleavage is necessary for proper epigenetic functions of the MLL complex, which are transcriptional maintenance and the genome-wide programming of cells during differentiation processes. Recently, we have identified that Taspase1 is also hydrolyzing the leukemogenic AF…
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Zitierempfehlung
S Sabiani, T Geppert, G Schneider, T Dingermann, R Marschalek (2010) Taspase1: unraveling its control mechanisms. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0030-1254492
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