CareLit · DOI-Nachweis · Klinische Pädiatrie
Modulation of DNA repair systems by the essential melanocyte transcription factor Microphthalmia
DOI 10.1055/s-0030-1254493
Bibliografische Angaben
Nachweis in CareLit
Autor:innenK Schwarzberg, E Bendrat, M Horstmann
ZeitschriftKlinische Pädiatrie
Ausgabe05/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The exponential increase of melanoma incidence is ultimately linked to UV exposure during childhood. We hypothesize that genomic stability is regulated by the melanocyte master regulator MITF which is essential for the development, survival and differentiation of melanocytes. Its master role is exemplified by the direct transcriptional regulation of Bcl-2, CDK2 and Tyrosinase. MITF expression is maintained throughou…
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Zitierempfehlung
K Schwarzberg, E Bendrat, M Horstmann (2010) Modulation of DNA repair systems by the essential melanocyte transcription factor Microphthalmia. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0030-1254493
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