CareLit · DOI-Nachweis · Klinische Pädiatrie
Hydroxyurea induces a senescent, non-malignant, immunogenic state in neuroblastoma cells – a new therapeutic strategy?
DOI 10.1055/s-0030-1254495
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Nachweis in CareLit
Autor:innenS Taschner-Mandl, A Kowalska, H Binder, D Rieder, Z Trajanoski, J Khan, F Speleman, I Ambros, P Ambros
ZeitschriftKlinische Pädiatrie
Ausgabe05/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Oncogene inactivation can cause cellular senescence, a permanent state of proliferative arrest, resulting in tumor “regression“. In MYCN-amplified (MNA) neuroblastoma (NB) long-term hydroxyurea (HU) treatment leads to the elimination of episomal MNA and senescence induction in vitro. The aim was to characterize senescent NB cells and describe their functional role. MLPA and arrayCGH confirmed that MNA is the only ch…
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Zitierempfehlung
S Taschner-Mandl, A Kowalska, H Binder, D Rieder, Z Trajanoski, J Khan, F Speleman, I Ambros, P Ambros (2010) Hydroxyurea induces a senescent, non-malignant, immunogenic state in neuroblastoma cells – a new therapeutic strategy?. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0030-1254495
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