CareLit · DOI-Nachweis · Klinische Pädiatrie
Small molecule XIAP inhibitors sensitize childhood acute leukemia cells for apoptosis induction and break Bcl-2-mediated resistance
DOI 10.1055/s-0030-1254498
Bibliografische Angaben
Nachweis in CareLit
Autor:innenM Fakler, S Loeder, M Vogler, K Schneider, I Jeremias, KM Debatin, S Fulda
ZeitschriftKlinische Pädiatrie
Ausgabe05/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Children with high risk acute lymphoblastic leukemia (ALL) do not respond well to current treatments which is in part due to defects in apoptosis signaling, e.g. overexpression of “Inhibitor of Apoptosis Proteins“ (IAPs). This highlights the demand to develop novel strategies that counter apoptosis resistance. Here, we report that XIAP inhibitors and Smac mimetics sensitize acute leukemia cells for death receptor- a…
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Zitierempfehlung
M Fakler, S Loeder, M Vogler, K Schneider, I Jeremias, KM Debatin, S Fulda (2010) Small molecule XIAP inhibitors sensitize childhood acute leukemia cells for apoptosis induction and break Bcl-2-mediated resistance. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0030-1254498
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