CareLit · DOI-Nachweis · Klinische Pädiatrie
shRNA-mediated silencing reveals distinct functions of ETV6/RUNX1 in leukemia
DOI 10.1055/s-0030-1254499
Bibliografische Angaben
Nachweis in CareLit
Autor:innenG Fuka, G Krapf, U Kaindl, M Kauer, M Dworzak, H Kantner, D Stoiber, R Panzer-Gruemayer
ZeitschriftKlinische Pädiatrie
Ausgabe05/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
ETV6/RUNX1 (ER) is expressed in 25% of childhood B-cell precursor ALL. It represents not only a first hit mutation but is also necessary for the maintenance of the leukemia phenotype. To confirm and extend our initial studies on the molecular function of the fusion protein, we used a lentiviral-mediated shRNA transfer to target ER. Its depletion led to decreased cellular proliferation and enhanced spontaneous apopto…
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Zitierempfehlung
G Fuka, G Krapf, U Kaindl, M Kauer, M Dworzak, H Kantner, D Stoiber, R Panzer-Gruemayer (2010) shRNA-mediated silencing reveals distinct functions of ETV6/RUNX1 in leukemia. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0030-1254499
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