CareLit · DOI-Nachweis · Klinische Pädiatrie
Effect of the HDAC inhibitor SAHA on the immunomodulatory properties of MSC and tumor stroma cells
DOI 10.1055/s-0030-1254501
Bibliografische Angaben
Nachweis in CareLit
Autor:innenA Kruchen, PD Johann, R Handgretinger, I Mueller
ZeitschriftKlinische Pädiatrie
Ausgabe05/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Histone deacetylase inhibitors, like suberoylanilide hydroxamic acid (SAHA), are potential new drugs in oncologic treatment protocols. They can impact on proliferation and function of T cells. We analysed the effects SAHA on T cells directly as well as on mesenchymal stromal cells (MSC), which are known to modulate T cell responses. SAHA reduced the suppressive effects of MSC on PBMC. In previous studies we found th…
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Zitierempfehlung
A Kruchen, PD Johann, R Handgretinger, I Mueller (2010) Effect of the HDAC inhibitor SAHA on the immunomodulatory properties of MSC and tumor stroma cells. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0030-1254501
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