CareLit · DOI-Nachweis · Klinische Pädiatrie
Bone mineral aposition rates in juvenile mice exposed to long-term imatinib
DOI 10.1055/s-0030-1254502
Bibliografische Angaben
Nachweis in CareLit
Autor:innenC Hoellerhage, J Vaitl, J Boehme, S Feldmann, J Tauer, J Gasser, M Suttorp
ZeitschriftKlinische Pädiatrie
Ausgabe05/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Imatinib (IMA) is highly effective in the therapy of chronic myeloid leukemia (CML) by inhibiting the constitutively active tyrosine kinase (TK) domain of the BCR-ABL fusion gene via competition for the ATP binding. However, IMA exhibits off-target effects and also binds to TKs like c-Kit, PDGF-R and c-FMS. As these TKs are ative in osteoblasts and osteoclasts, IMA impairs bone remodelling by inhibiting…
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Zitierempfehlung
C Hoellerhage, J Vaitl, J Boehme, S Feldmann, J Tauer, J Gasser, M Suttorp (2010) Bone mineral aposition rates in juvenile mice exposed to long-term imatinib. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0030-1254502
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