CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
The nucleotide composition of microsatellites impacts both replication fidelity and mismatch repair in human colorectal cells
DOI 10.1055/s-0030-1254629
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Autor:innenC Campregher, T Scharl, M Nemeth, C Honeder, T Jascur, CR Boland, C Gasche
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe05/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Microsatellite instability is a key mechanism of colon carcinogenesis. We have previously studied mutations within a (CA)13 microsatellite using an EGFP-based reporter-assay that allows the distinction of replication errors and mismatch repair activity. Here we utilize this assay to compare mutations of mono- and dinucleotide repeats in human colorectal cells. Methods: HCT116 and HCT116+chr3 cells were…
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Zitierempfehlung
C Campregher, T Scharl, M Nemeth, C Honeder, T Jascur, CR Boland, C Gasche (2010) The nucleotide composition of microsatellites impacts both replication fidelity and mismatch repair in human colorectal cells. Zeitschrift für Gastroenterologie (05). https://doi.org/10.1055/s-0030-1254629
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