CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
Mechanisms of genetically-determined diabetes resistance and susceptibility in db/db mice
DOI 10.1055/s-0030-1255186
Bibliografische Angaben
Nachweis in CareLit
Autor:innenA Lechner, R Puff, P Dames, M Weise, KG Parhofer, B Göke
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe05/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aims/Hypothesis: Leptin receptor-deficient db/db mice are a commonly used research model and it is known that the genetic background, on which the mutation is bred, modulates the mice's phenotype. While diabetes-resistant strains exhibit persistent hyperinsulinemia, susceptible backgrounds show progressive hyperglycemia and islet involution. The primary mechanisms of this phenotypic difference however are not known.…
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Zitierempfehlung
A Lechner, R Puff, P Dames, M Weise, KG Parhofer, B Göke (2010) Mechanisms of genetically-determined diabetes resistance and susceptibility in db/db mice. Diabetologie und Stoffwechsel (05). https://doi.org/10.1055/s-0030-1255186
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