CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
Role of glycotoxic metabolites & detoxifying mechanisms in aging & disease
DOI 10.1055/s-0030-1255197
Bibliografische Angaben
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Autor:innenT Fleming, TM Theilen, PM Humpert, PP Nawroth, A Bierhaus
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe05/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Methylglyoxal (MG) is a reactive metabolite generated from the metabolism of glucose. Increased formation of MG in vivo has been shown to be associated with the onset of tissue damage. MG and other endogenously formed dicarbonyl compounds can react with proteins to form Advanced Glycation Endproducts. Glyoxalase I (GLO1) is part of the glyoxalase system, and is the major cellular defence in the detoxification of MG.…
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Zitierempfehlung
T Fleming, TM Theilen, PM Humpert, PP Nawroth, A Bierhaus (2010) Role of glycotoxic metabolites & detoxifying mechanisms in aging & disease. Diabetologie und Stoffwechsel (05). https://doi.org/10.1055/s-0030-1255197
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