CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
The insulinotropic effect of fluoroquinolones is counteracted by their inhibitory effect on pancreatic beta cell energy metabolism
DOI 10.1055/s-0030-1255203
Bibliografische Angaben
Nachweis in CareLit
Autor:innenH Ghaly, K Hatlapatka, I Rustenbeck
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe05/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Rationale: Antimicrobial fluoroquinolones both stimulate and inhibit insulin secretion leading to hypo- and hyperglycemias, respectively. The insulinotropic effect is generally explained by their ability to block KATP channels in pancreatic beta cells. However, using metabolically intact primary beta cells we have found that fluoroquinolone concentrations which were sufficient to strongly inhibit KATP channel activi…
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Zitierempfehlung
H Ghaly, K Hatlapatka, I Rustenbeck (2010) The insulinotropic effect of fluoroquinolones is counteracted by their inhibitory effect on pancreatic beta cell energy metabolism. Diabetologie und Stoffwechsel (05). https://doi.org/10.1055/s-0030-1255203
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