CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
Analysis of submembrane insulin granule number and behavior during the initial phase of secretion – dynamic measurements using TIRF microscopy
DOI 10.1055/s-0030-1255204
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Autor:innenK Hatlapatka, M Matz, K Baumann, I Rustenbeck
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe05/2010
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Background and aims: The release of a pool of membrane-adjacent secretory granules which are in a primed and docked state and await one final trigger, a depolarization-induced influx of Ca2+, is held responsible for the first phase of glucose-induced insulin secretion. Recently, we observed that 15 mM K+ led to a 20 mV depolarization and to a lasting increase of the cytosolic Ca2+ concentration ([Ca2+]i), but only t…
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Zitierempfehlung
K Hatlapatka, M Matz, K Baumann, I Rustenbeck (2010) Analysis of submembrane insulin granule number and behavior during the initial phase of secretion – dynamic measurements using TIRF microscopy. Diabetologie und Stoffwechsel (05). https://doi.org/10.1055/s-0030-1255204
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