CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Truncated IRAG variants modulate cGMP mediated inhibition of human colonic smooth muscle cell contraction
DOI 10.1055/s-0030-1263720
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Autor:innenD Saur, D Oesterle, B Seidler, F Hofmann, M Schemann, RM Schmid, HD Allescher, G Schneider
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Nitric oxide (NO) mediates relaxation of colonic smooth muscle cells predominantly by cGMP/cGMP-dependent protein kinase I (cGKI)-induced phosphorylation of the IP3R-associated cGMP kinase substrate (IRAG) to block store-dependent calcium signaling. In the present study we analyzed the structure and function of the human IRAG gene. We describe four unique first exon variants transcribed from individual promoters in…
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Zitierempfehlung
D Saur, D Oesterle, B Seidler, F Hofmann, M Schemann, RM Schmid, HD Allescher, G Schneider (2010) Truncated IRAG variants modulate cGMP mediated inhibition of human colonic smooth muscle cell contraction. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0030-1263720
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