Distinct effect of galectins on the mononuclear phagocyte system

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Introduction: Monocytes and macrophages represent the link between the innate and adaptive immune systems and protect the host from the outside world. In inflammatory disorders, however, their activation leads to tissue damage. Galectins have emerged as central regulators of the immune system. Galectins are expressed by intestinal epithelial cells and bind to mucosal T cells. However, if and how they interfere with…

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