CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Panobinostat induces cell death through Endoplasmic Reticulum stress in hepatocellular cancer cells
DOI 10.1055/s-0030-1263796
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Autor:innenR Montalbano, P Di Fazio, T Wissniowski, S Gahr, K Quint, M Ocker
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2010
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Aims: Panobinostat (LBH589), a pan-deacetylase inhibitor, represents a novel therapeutic option for human cancer diseases. We have previously shown that panobinostat has a potent apoptotic activity in vitro and causes a significant growth delay of hepatocellular carcinoma (HCC) tumor xenografts in nude mice models. We have demonstrated that treatment with panobinostat is able to induce cell death in HepG2 (p53wt) an…
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Zitierempfehlung
R Montalbano, P Di Fazio, T Wissniowski, S Gahr, K Quint, M Ocker (2010) Panobinostat induces cell death through Endoplasmic Reticulum stress in hepatocellular cancer cells. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0030-1263796
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