CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
H2O2 rapidly activates the systemic iron hormone hepcidin independent of the IL-6/BMP6 network
DOI 10.1055/s-0030-1263852
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Autor:innenG Millonig, I Ganzleben, G Casanovas, T Peccerella, HK Seitz, MU Muckenthaler, S Mueller
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2010
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Aims: The liver-secreted peptide hepcidin is the key iron hormone at the systemic level. It decreases duodenal iron absorption and iron release by macrophages during conditions of excess iron by blocking the iron exporter ferroportin. In addition, IL-6 mediated upregulation of hepcidin during inflammation is the major mechanism of the so-called „anemia of chronic disease“. We here identify H2O2 which is co-released…
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Zitierempfehlung
G Millonig, I Ganzleben, G Casanovas, T Peccerella, HK Seitz, MU Muckenthaler, S Mueller (2010) H2O2 rapidly activates the systemic iron hormone hepcidin independent of the IL-6/BMP6 network. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0030-1263852
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