CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Association of common p53 and mdm2 variants with spontaneous and treatment induced viral clearance in patients with chronic hepatitis C infection
DOI 10.1055/s-0030-1263897
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Autor:innenV Zimmer, F Grünhage, M Krawczyk, G Assmann, S Zeuzem, C Sarrazin, F Lammert
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe08/2010
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Background & Aim: The tumor suppressor gene p53 has been implicated in the immune response to chronic hepatitis C virus (HCV) infection by modulation of interferon signalling (Dharel, Hepatology 2008). Common variants in p53 (SNP72 G/C) and its key negative regulator mdm2 (SNP309 T/G) affect p53′s apoptotic capacity and enhance mdm2 transcription, respectively (Whibley, Nat Rev Cancer 2009). We asked if these varian…
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Zitierempfehlung
V Zimmer, F Grünhage, M Krawczyk, G Assmann, S Zeuzem, C Sarrazin, F Lammert (2010) Association of common p53 and mdm2 variants with spontaneous and treatment induced viral clearance in patients with chronic hepatitis C infection. Zeitschrift für Gastroenterologie (08). https://doi.org/10.1055/s-0030-1263897
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