CareLit · DOI-Nachweis · Das Gesundheitswesen
Single nucleotide polymorphisms in Wnt signaling and apoptotic pathway genes and susceptibility to colorectal cancer
DOI 10.1055/s-0030-1266727
Bibliografische Angaben
Nachweis in CareLit
Autor:innenB Frank, M Hoffmeister, N Klopp, T Illig, J Chang-Claude, H Brenner
ZeitschriftDas Gesundheitswesen
Ausgabe09/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Constitutive activation of the canonical Wnt signaling pathway in consequence of mutations in APC, AXIN1 or CTNNB1 genes is regarded as initiating event in 90% of colorectal cancers (CRCs). Besides aberrant downstream target activation, numerous upstream Wnt signaling components were found deregulated in CRC. Additionally, Wnt signaling modulates apoptosis, encouraging CRC development and poor response…
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Zitierempfehlung
B Frank, M Hoffmeister, N Klopp, T Illig, J Chang-Claude, H Brenner (2010) Single nucleotide polymorphisms in Wnt signaling and apoptotic pathway genes and susceptibility to colorectal cancer. Das Gesundheitswesen (09). https://doi.org/10.1055/s-0030-1266727
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