CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Deficiency of phosphatidylinositol 3-kinase (PI3K) aggravates inflammation and fibrosis in experimental non alcoholic steatohepatitis but protects against bile duct ligation induced liver fibrosis in vivo
DOI 10.1055/s-0030-1267705
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Nachweis in CareLit
Autor:innenK Dostert, R Wiest, J Schölmerich, C Hellerbrand, E Gäbele
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe09/2010
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Background: Non alcoholic steatohepatitis (NASH) leads to liver fibrosis characterized by activation of hepatic stellate cells (HSC) and collagen expression. In vitro, we were able to show that PI3K participates in HSC proliferation and collagen expression. The aim of this study was to evaluate the role of PI3K in the development of experimental NASH and biliary fibrosis. Methods: Female PI3K knockout mice (PI3K–/–,…
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Zitierempfehlung
K Dostert, R Wiest, J Schölmerich, C Hellerbrand, E Gäbele (2010) Deficiency of phosphatidylinositol 3-kinase (PI3K) aggravates inflammation and fibrosis in experimental non alcoholic steatohepatitis but protects against bile duct ligation induced liver fibrosis in vivo. Zeitschrift für Gastroenterologie (09). https://doi.org/10.1055/s-0030-1267705
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