CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
In the presence of ethanol TGF-β effects switch from pro-survival to apoptotic in hepatocytes
DOI 10.1055/s-0030-1269457
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Autor:innenK Breitkopf-Heinlein, H Gaitantzi, Q Li, A Mueller, S Dooley
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Signalling of the pro-fibrogenic cytokine TGF-β is activated in liver disease including alcoholic liver disease (ALD). Since TGF-β was described as both, survival promoting or apoptosis inducing factor depending on the cellular context we analyzed its effects in combination with ethanol. The mild cytotoxic effects of ethanol or TGF-β on monolayer-cultured primary mouse hepatocytes is strongly enhanced when both subs…
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Zitierempfehlung
K Breitkopf-Heinlein, H Gaitantzi, Q Li, A Mueller, S Dooley (2011) In the presence of ethanol TGF-β effects switch from pro-survival to apoptotic in hepatocytes. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0030-1269457
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