CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Deficiency of phosphatidylinositol 3-kinase (PI3K) aggravates hepatic inflammation and fibrosis in experimental NASH but protects against bile duct ligation induced liver fibrosis
DOI 10.1055/s-0030-1269466
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Nachweis in CareLit
Autor:innenK Dostert, C Hellerbrand, E Gäbele
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2011
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Aims: Non alcoholic steatohepatitis (NASH) leads to liver fibrosis characterized by activation of hepatic stellate cells (HSC) and enhanced collagen expression. We were able to show that PI3K, an ubiquitary heterodimeric lipid kinase, participates in HSC proliferation and collagen expression. Therefore, the aim of this study was to evaluate the role of PI3K in experimental NASH and biliary fibrosis. Methods: PI3K kn…
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Zitierempfehlung
K Dostert, C Hellerbrand, E Gäbele (2011) Deficiency of phosphatidylinositol 3-kinase (PI3K) aggravates hepatic inflammation and fibrosis in experimental NASH but protects against bile duct ligation induced liver fibrosis. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0030-1269466
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