CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Molecular details on BMP-7 activity on TGF-beta1-mediated CTGF expression in myofibroblasts
DOI 10.1055/s-0030-1269467
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Autor:innenM Esser, R Weiskirchen, SK Meurer
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2011
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Background: In the setting of fibrogenic lesions, TGF-β1 drives cells to the myofibroblast phenotype and thereby causes excessive extracellular matrix (ECM) deposition. In the liver – as well as in other organs–BMP-7 has been described as an antifibrotic ligand abrogating profibrogenic TGF-β1 responses [1]. However, the exact molecular details of this antagonism have not been elucidated so far. To do so we employed…
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Zitierempfehlung
M Esser, R Weiskirchen, SK Meurer (2011) Molecular details on BMP-7 activity on TGF-beta1-mediated CTGF expression in myofibroblasts. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0030-1269467
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