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Bacterial translocation is associated with downregulation of Paneth cell antimicrobial peptides in ascitic cirrhotic but not in pre-hepatic portal hypertensive rats

Z Teltschik, J Beisner, S Nuding, E Stange, C Hofmann, C Bevins, J Schoelmerich, J Wehkamp, R Wiest · Zeitschrift für Gastroenterologie · Ausgabe 01/2011

DOI 10.1055/s-0030-1269503

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Autor:innenZ Teltschik, J Beisner, S Nuding, E Stange, C Hofmann, C Bevins, J Schoelmerich, J Wehkamp, R Wiest
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2011
Jahrgang / SeitenNicht angegeben

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Aims: Many complications in portal hypertension limiting prognosis are triggered by bacterial translocation (BT) which is defined as the migration of bacteria from the intestinal lumen to mesenteric lymph nodes (MLN) and/or other extraintestinal sites. Most translocating bacteria belong to the common intestinal flora which suggests a breakdown of mucosal barrier function. We hypothesized that BT in portal hypertensi…

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Z Teltschik, J Beisner, S Nuding, E Stange, C Hofmann, C Bevins, J Schoelmerich, J Wehkamp, R Wiest (2011) Bacterial translocation is associated with downregulation of Paneth cell antimicrobial peptides in ascitic cirrhotic but not in pre-hepatic portal hypertensive rats. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0030-1269503

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