CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Antifibrotic effects of adiponectin include induction of BMP-activated and membrane bound inhibitor (Bambi) in liver cells which antagonizes TGF-beta activity
DOI 10.1055/s-0030-1269506
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Nachweis in CareLit
Autor:innenJ Wanninger, M Neumeier, S Bauer, TS Weiss, C Hellerbrand, J Schoelmerich, C Buechler
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Objectives: TGF-beta induces activation of hepatic stellate cells and an epithelial mesenchymal transition of hepatocytes, and thereby promotes the progression of liver fibrosis. BMP-activated and membrane bound inhibitor (Bambi) mimics TGF-beta receptor I, but lacks an intracellular kinase domain and interaction of Bambi with TGF-beta receptor II results in a non functional TGF-beta pseudoreceptor. Adiponectin, who…
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Zitierempfehlung
J Wanninger, M Neumeier, S Bauer, TS Weiss, C Hellerbrand, J Schoelmerich, C Buechler (2011) Antifibrotic effects of adiponectin include induction of BMP-activated and membrane bound inhibitor (Bambi) in liver cells which antagonizes TGF-beta activity. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0030-1269506
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