CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
De novo lipogenesis is required for insulin-mediated hepatocarcinogenesis and contributes to human liver cancer prognosis
DOI 10.1055/s-0030-1269528
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Autor:innenDF Calvisi, K Evert, V De Murtas, G Gasparetti, G Destefanis, S Mattu, F Dombrowski, M Evert
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
To study the oncogenic effect of chronic and elevated secretion of insulin on hepatocytes in the presence of mild hyperglycemia, we developed a model of pancreatic islet transplantation into the liver via the portal vein. In this model, islets of a donor rat are transplanted into the liver of a recipient diabetic rat, with resulting local hyperinsulinism that leads to the development of preneoplastic lesions and hep…
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Zitierempfehlung
DF Calvisi, K Evert, V De Murtas, G Gasparetti, G Destefanis, S Mattu, F Dombrowski, M Evert (2011) De novo lipogenesis is required for insulin-mediated hepatocarcinogenesis and contributes to human liver cancer prognosis. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0030-1269528
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