CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Ursodeoxycholyl Lysophosphatidylethanolamide (UDCA-LPE) Protects Mouse Hepatocytes from Lipoapoptosis by Upregulating Stearoyl-CoA Desaturase-1
DOI 10.1055/s-0030-1269530
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Nachweis in CareLit
Autor:innenW Chamulitrat, W Xu, N Katava, A Pathil, W Stremmel
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2011
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Introduction: We had previously shown that UDCA-LPE induced activation of cell survival PI3K/Akt and ERK1/2 pathways, and inhibited TNF-alpha-induced apoptosis in hepatocyte cell lines. Our goals are to demonstrate protective role of UDCA-LPE from lipotoxicity in primary mouse hepatocytes, and to delineate mechanism of action involving G-protein coupled receptor (GPCR) and the synthesis of triglycerides (TG) that ar…
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Zitierempfehlung
W Chamulitrat, W Xu, N Katava, A Pathil, W Stremmel (2011) Ursodeoxycholyl Lysophosphatidylethanolamide (UDCA-LPE) Protects Mouse Hepatocytes from Lipoapoptosis by Upregulating Stearoyl-CoA Desaturase-1. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0030-1269530
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