CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Human keratin 8 variants predispose to acetaminophen toxicity
DOI 10.1055/s-0030-1269544
Bibliografische Angaben
Nachweis in CareLit
Autor:innenN Güldiken, Q Zhou, O Kucukoglu, G Adler, MB Omary, P Strnad
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background and Aims: Keratins 8 and 18 (K8/K18) are the intermediate filaments of digestive epithelia and display an important cytoprotective function. Accordingly, K8/K18 variants predispose humans to chronic liver disease development/progression and to acute acetaminophen toxicity. Given that K8 G62C and K8 R341H are the most common K8 variants in Caucasians, we studied their hitherto unknown molecular effects in…
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Zitierempfehlung
N Güldiken, Q Zhou, O Kucukoglu, G Adler, MB Omary, P Strnad (2011) Human keratin 8 variants predispose to acetaminophen toxicity. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0030-1269544
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