CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Human liver cell cultivation for long-term in vitro toxicity studies in a miniaturized multi-compartment 3D bioreactor system
DOI 10.1055/s-0030-1269553
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Autor:innenSA Hoffmann, M Lübberstedt, U Müller-Vieira, D Knobeloch, A Nüssler, JC Gerlach, K Zeilinger
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Classical model systems of hepatotoxicity have profound limitations in adequately assessing drug toxicity: Results from animal experiments cannot necessarily be extrapolated to humans; primary human hepatocytes lose their specific metabolic functions within short time in conventional 2D cell culture. Based on a liver cell bioreactor for clinical use in an extracorporeal liver support system employing hollow fiber pe…
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Zitierempfehlung
SA Hoffmann, M Lübberstedt, U Müller-Vieira, D Knobeloch, A Nüssler, JC Gerlach, K Zeilinger (2011) Human liver cell cultivation for long-term in vitro toxicity studies in a miniaturized multi-compartment 3D bioreactor system. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0030-1269553
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