CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Expression of the organic anion transporters OATP1B1, OATP1B3, and OATP2B1 in human liver is affected by genetic and nongenetic factors
DOI 10.1055/s-0030-1269580
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Nachweis in CareLit
Autor:innenA Nies
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Transport proteins in the sinusoidal membrane of hepatocytes mediate drug uptake, which is required for hepatic drug metabolism and elimination. Anionic drugs (e.g. statins, methotrexate, digoxin, paclitaxel) may be taken up into the hepatocytes by members of the organic anion transporting polypeptide (OATP) family, i.e. OATP1B1 (gene symbol SLCO1B1), OATP1B3 (SLCO1B3), and OATP2B1 (SLCO2B1) [1]. As interindividual…
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Zitierempfehlung
A Nies (2011) Expression of the organic anion transporters OATP1B1, OATP1B3, and OATP2B1 in human liver is affected by genetic and nongenetic factors. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0030-1269580
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