CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Apoptosis sensitization of hepatocytes by acyl-CoA synthetase 5 involves deregulation of sphingolipid metabolism and alterations in mitochondrial signalling
DOI 10.1055/s-0030-1269585
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Autor:innenA Reinartz, C Haynes, R Knuechel, R Weiskirchen, A Merrill, N Gassler
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Fatty acid accumulation in hepatocytes and subsequent hepatocyte lipoapoptosis are key features in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and associated acute and chronic liver injury. The initial step in fatty acid and lipid metabolism is the activation of fatty acids catalyzed by long chain acyl-CoA synthetases (ACSL). ACSL5, a mitochondrially located isoform that is upregulated in hepatic st…
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Zitierempfehlung
A Reinartz, C Haynes, R Knuechel, R Weiskirchen, A Merrill, N Gassler (2011) Apoptosis sensitization of hepatocytes by acyl-CoA synthetase 5 involves deregulation of sphingolipid metabolism and alterations in mitochondrial signalling. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0030-1269585
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