CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
A human hepatic 3D-cell culture model for basic research, preclinical drug metabolism and toxicity testing
DOI 10.1055/s-0030-1269591
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Nachweis in CareLit
Autor:innenC Schäfer, MR Lornejad-Schäfer, KR Schröder
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: Drug-induced toxicity is a main cause of acute liver failure. To test drug metabolism and toxicity and to reduce adverse drug reactions and animal experimentation, highly predictive human hepatic in vitro models are strong requested. We have established a three-dimensional (3D) liver cell model for drug discovery, maintaining liver-specific functions in the longer term. Methods: HepaRG, a human progeni…
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Zitierempfehlung
C Schäfer, MR Lornejad-Schäfer, KR Schröder (2011) A human hepatic 3D-cell culture model for basic research, preclinical drug metabolism and toxicity testing. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0030-1269591
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