CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
The pan-deacetylase inhibitor panobinostat (LBH 589) inhibits DNA methyltransferases in HCC in vitro and in vivo
DOI 10.1055/s-0030-1269612
Bibliografische Angaben
Nachweis in CareLit
Autor:innenS Zopf, P Di Fazio, S Gahr, D Strobel, MF Neurath, M Ocker
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The novel cinnamic hydroxamic acid pan-deacetylase inhibitor panobinostat (LBH 589) has recently described to posesss cytotoxic effects against HCC by inhibition of protein deacetylases and histone deacetylases. We therefore applied panobinostat to human HCC cell lines (HepG2, Hep3B) in vitro and to a xenograft model in vivo to determine its effect on another epigenetic target, the DNA methyltransferases (DNMT´s).Th…
Zitieren
Zitierempfehlung
S Zopf, P Di Fazio, S Gahr, D Strobel, MF Neurath, M Ocker (2011) The pan-deacetylase inhibitor panobinostat (LBH 589) inhibits DNA methyltransferases in HCC in vitro and in vivo. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0030-1269612
Mit CareLit weiterarbeiten