CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Functional exhaustion of virus specific CD8+ T-cell immunity in fibrotic liver leads to viral persistence
DOI 10.1055/s-0030-1269656
Bibliografische Angaben
Nachweis in CareLit
Autor:innenZ Abdullah, J Trebicka, PA Knolle
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
The impact of liver fibrosis or cirrhosis on hepatic immune regulation is unkown. Here we addressed the impact of fibrotic liver diseases on virus-specific immune response. Liver fibrosis and cirrhosis was induced in mice by CCl4 treatment prior to infection with the lymphocytic choriomeningitis virus (LCMV). On day 8, 10 and 14 post infection viral load and effector functions of virus specific immune cells were det…
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Zitierempfehlung
Z Abdullah, J Trebicka, PA Knolle (2011) Functional exhaustion of virus specific CD8+ T-cell immunity in fibrotic liver leads to viral persistence. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0030-1269656
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