CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
The non-specific activation of liver tissue by siRNAs in vivo can be controlled by chemical ribose modifications of siRNAs
DOI 10.1055/s-0030-1269661
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Nachweis in CareLit
Autor:innenR Bröring, C Real, K Jahn-Hofmann, L Ickenstein, M John, K Kleinehr, G Gerken, JF Schlaak
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: siRNAs have been developed for therapeutic use in liver cancer, viral hepatitis or metabolic disorders. We previously showed that chemical modification of siRNAs control immunologically mediated off-target effects in isolated liver cells in vitro. In the present study, we assessed efficacy and immune-stimulatory effects of these siRNAs in vivo. Methods: Human and murine hepatocytes and non-parenchymal…
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Zitierempfehlung
R Bröring, C Real, K Jahn-Hofmann, L Ickenstein, M John, K Kleinehr, G Gerken, JF Schlaak (2011) The non-specific activation of liver tissue by siRNAs in vivo can be controlled by chemical ribose modifications of siRNAs. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0030-1269661
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