CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
The role of non-professional liver APCs for tolerance induction in the mouse model of concanavalin A-induced liver injury
DOI 10.1055/s-0030-1269663
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Nachweis in CareLit
Autor:innenS Burghardt, A Erhardt, G Tiegs
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Objectives: A single injection of concanavalin A (ConA) in mice induces acute Th1-mediated hepatitis. Tolerance against ConA rechallenge develops within 8 days mediated by IL-10-producing CD4+CD25+FoxP3+ regulatory T cells (Tregs). This study was intended to identify the contribution of hepatocytes (HC) to ConA tolerance by inducing a regulatory phenotype in naïve T cells. Methods: HC were isolated from saline- or C…
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Zitierempfehlung
S Burghardt, A Erhardt, G Tiegs (2011) The role of non-professional liver APCs for tolerance induction in the mouse model of concanavalin A-induced liver injury. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0030-1269663
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