CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Common Vitamin D Receptor (NR 1I1) gene polymorphisms and 25-OH vitamin D serum levels influence fibrosis progression and hepatic MMP-9 expression in chronic hepatitis C patients
DOI 10.1055/s-0030-1269687
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Autor:innenJC Mertens, K Baur, J Schmitt, R Iwata, B Stieger, P Frei, A Al-Deb'i, B Seifert, B Müllhaupt, A Geier
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2011
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Aims: The vitamin D receptor (VDR) pathway mediates antiinflammatory and antifibrotic effects in hepatic stellate cells. In chronic HCV pts, 25-OH-vitamin D levels are associated with stage of fibrosis and inflammation. We examined if VDR gene polymorphisms (SNP) and low serum vitamin D lead to altered hepatic gene expression and rapid fibrosis progression in HCV pts. Methods: 251 HCV pts received VDR genotyping (Cd…
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Zitierempfehlung
JC Mertens, K Baur, J Schmitt, R Iwata, B Stieger, P Frei, A Al-Deb'i, B Seifert, B Müllhaupt, A Geier (2011) Common Vitamin D Receptor (NR 1I1) gene polymorphisms and 25-OH vitamin D serum levels influence fibrosis progression and hepatic MMP-9 expression in chronic hepatitis C patients. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0030-1269687
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