CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
CD8+ T cell selection pressure is a major driving force for evolution of hepatitis C virus nonstructural proteins
DOI 10.1055/s-0030-1269693
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Autor:innenM Ruhl, T Knuschke, K Schewior, M Wiese, H Tenckhoff, U Spengler, J Nattermann, D Hoffmann, J Timm
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2011
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Aims: Mutational escape from immune pressure exacted by CD8 T cells has been described during infection with hepatitis C virus (HCV). However, the extent to which this immune adaptation process contributes to viral evolution at the population level is less clear. Here, we took advantage of a large HCV genotype 1b outbreak after inoculation of contaminated immunoglobulins in 1977/78 to study this adaptation process.…
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Zitierempfehlung
M Ruhl, T Knuschke, K Schewior, M Wiese, H Tenckhoff, U Spengler, J Nattermann, D Hoffmann, J Timm (2011) CD8+ T cell selection pressure is a major driving force for evolution of hepatitis C virus nonstructural proteins. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0030-1269693
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