CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Antiproliferative and antiviral effects of mutated IFN-alpha with increased IFN receptor binding affinity
DOI 10.1055/s-0030-1269699
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Autor:innenMF Sprinzl, L Bührer, D Strand, G Schreiber, PR Galle, J Piehler, M Schuchmann
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: IFN receptors located on the cellular membrane transduce IFN dependent signals and activate antiviral and antiproliferative effects. In this project we characterized the antiviral and antiproliferative action of mutated IFN-alpha (IFN-HEQ), which shows an increased affinity to IFNR1 compared to wild type IFN-alpha. Methods: Subgenomic HCV replicons (Huh7-HCVluc), which contain a luciferase reporter, were…
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Zitierempfehlung
MF Sprinzl, L Bührer, D Strand, G Schreiber, PR Galle, J Piehler, M Schuchmann (2011) Antiproliferative and antiviral effects of mutated IFN-alpha with increased IFN receptor binding affinity. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0030-1269699
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