CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Enzymatic activity of Phosphatidyl-inositol-4 kinase III alpha (PI4KIIIα) is critically involved in HCV replication and regulated by HCV NS5A
DOI 10.1055/s-0030-1269705
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Nachweis in CareLit
Autor:innenS Reiss, I Rebhan, P Backes, T Longerich, P Schirmacher, R Bartenschlager, V Lohmann
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2011
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
PI4KIIIα has been identified as important host factor for HCV replication (1). To gain insight into the mechanism of action, we generated cell lines with a stable knock-down of PI4KIIIα, resulting in a significant reduction of HCV replication upon infection with replication competent genomes. Interestingly, upon expression of non-structural proteins NS3–5B the structure of HCV induced membrane alterations was differ…
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Zitierempfehlung
S Reiss, I Rebhan, P Backes, T Longerich, P Schirmacher, R Bartenschlager, V Lohmann (2011) Enzymatic activity of Phosphatidyl-inositol-4 kinase III alpha (PI4KIIIα) is critically involved in HCV replication and regulated by HCV NS5A. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0030-1269705
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