CareLit · DOI-Nachweis · Klinische Pädiatrie
Targeting the IGF1 Pathway in Pediatric Sarcomas
DOI 10.1055/s-0030-1270296
Bibliografische Angaben
Nachweis in CareLit
Autor:innenLJ Helman
ZeitschriftKlinische Pädiatrie
Ausgabe12/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
We have previously demonstrated that IGFIR signaling plays a significant role in the growth and survival of pediatric sarcomas. We also showed that the survival signal provided by the IGFIR was in part mediated by activation of mTOR signaling, suggesting that combination therapy with IGFIR inhibition and mTOR inhibition may be advantageous. Preclinical studies using a human IGFIR moAb's confirmed the activity agains…
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Zitierempfehlung
LJ Helman (2010) Targeting the IGF1 Pathway in Pediatric Sarcomas. Klinische Pädiatrie (12). https://doi.org/10.1055/s-0030-1270296
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