CareLit · DOI-Nachweis · Klinische Pädiatrie
Targeting Epigenetic Maintenance of Stemness in Pediatric Malignancy
DOI 10.1055/s-0030-1270299
Bibliografische Angaben
Nachweis in CareLit
Autor:innenS Burdach
ZeitschriftKlinische Pädiatrie
Ausgabe12/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
A shift of the focus in cancer research from genetic to epigenetic mechanisms can be observed during the last five years. Chromatin modifications are increasingly recognized as a key mechanism. The histone methyl-transferase Enhancer of Zeste, Drosophila, Homolog 2 (EZH2) is the enzymatic subunit of the polycomb PRC2 complex and methylates histone H3K27, thereby, mediating gene silencing. EZH2 is over-expressed in a…
Zitieren
Zitierempfehlung
S Burdach (2010) Targeting Epigenetic Maintenance of Stemness in Pediatric Malignancy. Klinische Pädiatrie (12). https://doi.org/10.1055/s-0030-1270299
Mit CareLit weiterarbeiten