CareLit · DOI-Nachweis · Klinische Pädiatrie
Targeting TRAIL Death Receptors: TRAIL from the Lab to the Clinic
DOI 10.1055/s-0030-1270301
Bibliografische Angaben
Nachweis in CareLit
Autor:innenS De Jong, EGE De Vries
ZeitschriftKlinische Pädiatrie
Ausgabe12/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo2L) induces apoptosis upon ligation of its death domain-containing transmembrane receptors DR4 (TRAIL-R1) and DR5 (TRAIL-R2) via activation of the extrinsic apoptosis pathway. Recombinant human (rh) TRAIL induces cell death in ˜ 50% of the cancers cell lines but not in normal cells. Apoptosis by rhTRAIL can be enhanced by DNA damaging drugs. Recently,…
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Zitierempfehlung
S De Jong, EGE De Vries (2010) Targeting TRAIL Death Receptors: TRAIL from the Lab to the Clinic. Klinische Pädiatrie (12). https://doi.org/10.1055/s-0030-1270301
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